Plant Description

Ephedra is a shrub that is native to Pakistan, China, and northwestern India. Some ephedra species grow in the Southwest desert of the United States. The ephedra plant is a perennial evergreen that stands 1 foot high, on average. But it may grow up to 4 feet. Nearly leafless, the plant has slender, cylindrical, yellow-green branches and underground runners. In August, the flowers bear poisonous, fleshy, red cones resembling berries. The 3 ephedra species, ephedra sinica , ephedra equisetina , and ephedra intermedia , are collectively known by their Chinese name ma huang.

Parts Used

The young stems and branchlets are the parts used for medicinal preparations.

Medicinal Uses and Indications

Ephedra is primarily used to treat:

• Asthma
• Cough
• Bronchitis
• Allergic rhinitis
• Sinusitis
• Nasal congestion

Available Forms

Ephedra can come in dried or liquid form. It can be taken as a tablet, capsule, or as a tea to drink.

How to Take It

Ephedra should be used only on a short-term basis because prolonged use may lead to addiction. The amount of time considered safe, however, is not clear. Use of ephedra should take place only under the guidance and supervision of an appropriately-trained specialist. Ephedra should be taken between meals, without food.

Pediatric

The American Botanical Council warns that anyone under the age of 18 should not use ephedra without strict medical supervision.

Adult

Ephedra supplements have been banned from the U.S. market. People living outside of the U.S. should use caution, and work with a highly trained practioner when considering the use of ephedra.

Precautions

Herbs contain active substances that can trigger side effects and interact with other herbs, supplements, or medications. For these reasons, you should take herbs only under the supervision of a health care provider knowledgeable in the field of botanical medicine.

Ephedra can produce side effects, such as irritability, restlessness, anxiety, insomnia, headaches, nausea, vomiting, and urinary problems. More serious side effects include high blood pressure, rapid or irregular heartbeat, stroke, seizures, addiction, and even death. If you experience any of these adverse effects, discontinue using ephedra and contact your provider immediately.

You should not take ephedra if you have the following health conditions: anxiety, depression, high blood pressure, glaucoma, heart disease, prostate enlargement, difficulty urinating, seizure disorder, impaired circulation to the brain, psychiatric disorders, thyroid disorders, or diabetes. Anyone taking medications for high blood pressure or depression, and women who are pregnant or breastfeeding, should avoid ephedra and ephedra alkaloids such as ephedrine. To determine whether ephedra is safe and appropriate for you, consult a knowledgeable provider.

Possible Interactions

While no specific interactions (positive or negative) between the herb ephedra and conventional medications have been reported, the active ingredients of ephedra, ephedrine, and pseudoephedrine have been associated with several serious drug interactions. We may assume, for safety's sake, that drugs that interact with ephedra's active ingredients may also interact with the herb ephedra. Medications for which there are well documented interactions with ephedra's active ingredients include, but are not limited to:

• Amphetamine and amphetamine derivatives. Amphetamine and amphetamine derivatives (such as dextroamphetamine, sometimes used for attention deficit hyperactivity disorder and narcolepsy) should not be used with ephedra. Ephedra may cause increased effects of amphetamines on the body, such as increased heart rate and blood pressure.
• Antidepressants. Ephedra may interact with antidepressants, namely those in the class of tricyclics (such as clomipramine, desipramine, doxepin, imipramine, and nortriptyline) and monoamine oxidase inhibitors (MAOIs, including phenelzine and trancylcypromine).
• Aspirin and blood-thinning medications. Ephedra may increase bleeding in sensitive individuals, such as those taking aspirin or other blood-thinning medications.
• Blood pressure medications. Ephedra may interact with blood pressure lowering medications, particularly clonidine.
• Caffeine and guarana (a caffeine containing herb)
• Narcotics. Ephedra may interact with narcotics prescribed for pain, such as morphine and codeine; codeine may also be prescribed for cough.
• Theophylline. Ephedra may interact with theophylline (used for asthma).

Supporting Research

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