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Muscle biopsy
Biopsy - muscle
A muscle biopsy is the removal of a small piece of muscle tissue for examination.
How the Test is Performed
This procedure is usually done while you are awake. The health care provider will apply a numbing medicine (local anesthesia) to the biopsy area.
There are 2 types of muscle biopsy:
- A needle biopsy involves inserting a needle into the muscle. When the needle is removed, a small piece of tissue remains in the needle. More than one needle stick may be needed to get a large enough sample.
- An open biopsy involves making a small cut in the skin and into the muscle. The muscle tissue is then removed.
After either type of biopsy, the tissue is sent to a laboratory for examination.
How to Prepare for the Test
No special preparation is usually needed. If you will have anesthesia, follow instructions on not eating or drinking anything before the test.
How the Test will Feel
During the biopsy, there is usually little or no discomfort. You may feel some pressure or tugging.
The anesthetic may burn or sting when injected (before the area becomes numb). After the anesthetic wears off, the area may be sore for about a week.
Why the Test is Performed
A muscle biopsy may be done to identify or detect:
-
Inflammatory diseases of muscle (such as
polymyositis
or
dermatomyositis
)
Polymyositis
Polyarteritis nodosa is a serious blood vessel disease. The small and medium-sized arteries become swollen and damaged.
ImageRead Article Now Book Mark ArticleDermatomyositis
Polymyositis is a rare inflammatory disease. It leads to muscle weakness, swelling tenderness, and tissue damage. It is part of a larger group of d...
ImageRead Article Now Book Mark Article - Diseases of the connective tissue and blood vessels (such as polyarteritis nodosa)
-
Infections that affect the muscles (such as
trichinosis
or
toxoplasmosis
)
Trichinosis
Trichinosis is an infection with the roundworm Trichinella spiralis.
ImageRead Article Now Book Mark ArticleToxoplasmosis
Toxoplasmosis is an infection due to the parasite Toxoplasma gondii.
ImageRead Article Now Book Mark Article -
Inherited muscle disorders such as
muscular dystrophy
or congenital myopathy
Muscular dystrophy
Muscular dystrophy is a group of inherited disorders that cause muscle weakness and loss of muscle tissue, which get worse over time.
ImageRead Article Now Book Mark Article - Metabolic defects of the muscle
-
Effects of medicines, toxins, or
electrolyte
disorders
Electrolyte
Electrolytes are minerals in your blood and other body fluids that carry an electric charge. Electrolytes affect how your body functions in many ways...
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A muscle biopsy may also be done to tell the difference between nerve and muscle disorders.
A muscle that has recently been injured, such as by an EMG needle, or is affected by a pre-existing condition, such as nerve compression, is not a good choice for a biopsy.
EMG
Electromyography (EMG) is a test that checks the health of the muscles and the nerves that control the muscles.
Normal Results
A normal result means the muscle is normal.
What Abnormal Results Mean
A muscle biopsy can help diagnose the following conditions:
-
Loss of muscle mass (
atrophy)
Atrophy)
Muscle atrophy is the wasting or loss of muscle tissue.
ImageRead Article Now Book Mark Article -
Muscle disease that involves inflammation and a skin rash (
dermatomyositis
)
Dermatomyositis
Dermatomyositis is a muscle disease that involves inflammation and a skin rash. It is a type of inflammatory myopathy.
ImageRead Article Now Book Mark Article -
Inherited muscle disorder (
Duchenne muscular dystrophy
)
Duchenne muscular dystrophy
Duchenne muscular dystrophy is an inherited disorder. It involves muscle weakness, which quickly gets worse.
ImageRead Article Now Book Mark Article - Inflammation of the muscle
- Various muscular dystrophies
-
Destruction of the muscle (
myopathic changes
)
Myopathic changes
A muscle disorder includes patterns of weakness, electromyogram (EMG) findings, or biopsy results that suggest a muscle problem. The muscle disorder...
ImageRead Article Now Book Mark Article -
Tissue death of the muscle
(necrosis)
(necrosis)
Necrosis is the death of body tissue. It occurs when too little blood flows to the tissue. This can be from injury, radiation, or chemicals. Necro...
ImageRead Article Now Book Mark Article -
Disorders that involve inflammation of the blood vessels and affect muscles (
necrotizing vasculitis
)
Necrotizing vasculitis
Necrotizing vasculitis is a group of disorders that involve inflammation of the blood vessel walls. The size of the affected blood vessels helps to ...
ImageRead Article Now Book Mark Article - Traumatic muscle damage
- Paralyzed muscles
-
Inflammatory disease causing muscle weakness, swelling tenderness, and tissue damage (
polymyositis
)
Polymyositis
Polymyositis is a rare inflammatory disease. It leads to muscle weakness, swelling tenderness, and tissue damage. It is part of a larger group of d...
ImageRead Article Now Book Mark Article - Nerve problems that affect the muscles
-
Muscle tissue under the skin (fascia) becomes swollen, inflamed, and thick (
eosinophilic fasciitis
)
Eosinophilic fasciitis
Eosinophilic fasciitis is a syndrome in which muscle tissue under the skin, called fascia, becomes swollen, inflamed and thick. The hands, arms, leg...
ImageRead Article Now Book Mark Article
There are additional conditions under which the test may be performed.
Risks
The risks of this test are small, but may include:
- Bleeding
-
Bruising
Bruising
Bleeding into the skin can occur from broken blood vessels that form tiny red dots (called petechiae). Blood also can collect under the tissue in la...
ImageRead Article Now Book Mark Article - Damage to the muscle tissue or other tissues in the area (very rare)
- Infection (a slight risk any time the skin is broken)
References
Dubowitz V, Sewry CA, Oldfors A. The procedure of muscle biopsy. In: Dubowitz V, Sewry CA, Oldfors A, eds. Muscle Biopsy: A Practical Approach . 4th ed. Philadelphia, PA: Elsevier Saunders; 2013:chap 1.
-
Muscle biopsy - illustration
A muscle biopsy involves removal of a plug of tissue usually by a needle to be later used for examination. Sometimes more than one needle insertion may be needed to obtain a large enough specimen. If there is a patchy condition expected an open biopsy may be used. Open biopsy involves a small incision through the skin and into the muscle, so that a sample of muscle tissue can be removed from the affected area. There may be some slight bruising or bleeding at the site but the risks are minimal with the procedure.
Muscle biopsy
illustration
-
Muscle biopsy - illustration
A muscle biopsy involves removal of a plug of tissue usually by a needle to be later used for examination. Sometimes more than one needle insertion may be needed to obtain a large enough specimen. If there is a patchy condition expected an open biopsy may be used. Open biopsy involves a small incision through the skin and into the muscle, so that a sample of muscle tissue can be removed from the affected area. There may be some slight bruising or bleeding at the site but the risks are minimal with the procedure.
Muscle biopsy
illustration
Review Date: 7/21/2016
Reviewed By: Gordon A. Starkebaum, MD, Professor of Medicine, Division of Rheumatology, University of Washington School of Medicine, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.
