Calcium blood test
Ca+2; Serum calcium; Ca++; Hyperparathyroidism - calcium level; Osteoporosis - calcium level; Hypercalcemia - calcium level; Hypocalcemia - calcium level
The calcium blood test measures the level of calcium in the blood.
This article discusses the test to measure the total amount of calcium in your blood. About half of the calcium in the blood is attached to proteins, mainly albumin.
A separate test that measures calcium that is not attached to proteins in your blood is sometimes performed. Such calcium is called free or ionized calcium .
Separate test
Ionized calcium is calcium in your blood that is not attached to proteins. It is also called free calcium. All cells need calcium in order to work. ...
Ionized calcium
Ionized calcium is calcium in your blood that is not attached to proteins. It is also called free calcium. All cells need calcium in order to work. ...
Calcium can also be measured in the urine .
Urine
This test measures the amount of calcium in urine. All cells need calcium in order to work. Calcium helps build strong bones and teeth. It is impo...
How the Test is Performed
A blood sample is needed.
Blood sample
Venipuncture is the collection of blood from a vein. It is most often done for laboratory testing.
How to Prepare for the Test
Your health care provider may tell you to temporarily stop taking certain medicines that can affect the test. These medicines may include:
- Calcium salts (may be found in nutritional supplements or antacids)
- Lithium
- Thiazide diuretics (water pills)
- Thyroxine
- Vitamin D
Drinking too much milk (2 or more quarts or 2 liters a day or a large amount of other dairy products) or taking too much vitamin D as a dietary supplement can also increase blood calcium levels.
How the Test will Feel
When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or slight bruising. This soon goes away.
Why the Test is Performed
All cells need calcium in order to work. Calcium helps build strong bones and teeth. It is important for heart function, and helps with muscle contraction, nerve signaling, and blood clotting.
Your doctor may order this test if you have signs or symptoms of:
- Certain bone diseases
- Certain cancers, such as multiple myeloma, a cancer of the breast, lung, neck, and kidney
-
Chronic kidney disease
Chronic kidney disease
Chronic kidney disease is the slow loss of kidney function over time. The main job of the kidneys is to remove wastes and excess water from the body...
-
Chronic liver disease
Chronic liver disease
Cirrhosis is scarring of the liver and poor liver function. It is the last stage of chronic liver disease.
- Disorders of the parathyroid glands (hormone made by these glands controls calcium and vitamin D levels in the blood)
- Disorders that affect how your intestines absorb nutrients
- Overactive thyroid gland or taking too much thyroid hormone medicine
- Abnormal vitamin D level
Your doctor may also order this test if you have been on bed rest for a long time.
Normal Results
Normal values range from 8.5 to 10.2 mg/dL (2.13 to 2.55 millimol/L).
Normal value ranges may vary slightly among different laboratories. Some laboratories use different measurements or may test different specimens. Talk to your doctor about the meaning of your specific test results.
What Abnormal Results Mean
A higher than normal level may be due to a number of health conditions. Common causes include:
- Being on bed rest for a long time.
- Consuming too much calcium or vitamin D.
-
Hyperparathyroidism
(parathyroid glands make too much of their hormone; often associated with a low vitamin D level).
Hyperparathyroidism
Hyperparathyroidism is a disorder in which the parathyroid glands in your neck produce too much parathyroid hormone (PTH).
- Infections that cause granulomas such as tuberculosis and certain fungal and mycobacterial infections.
-
Multiple myeloma
, T cell lymphoma and certain other cancers.
Multiple myeloma
A bone tumor is an abnormal growth of cells within a bone. A bone tumor may be cancerous (malignant) or noncancerous (benign).
-
Metastatic bone tumor
(bone cancer that has spread).
Metastatic bone tumor
A bone tumor is an abnormal growth of cells within a bone. A bone tumor may be cancerous (malignant) or noncancerous (benign).
- Overactive thyroid gland (hyperthyroidism) or too much thyroid hormone replacement medicine.
-
Paget disease
. Abnormal bone destruction and regrowth, causing deformity of the affected bones.
Paget disease
Paget disease is a disorder that involves abnormal bone destruction and regrowth. This results in deformity of the affected bones.
-
Sarcoidosis
. Lymph nodes, lungs, liver, eyes, skin, or other tissues become swollen or inflamed.
Sarcoidosis
Sarcoidosis is a disease in which inflammation occurs in the lymph nodes, lungs, liver, eyes, skin, or other tissues.
- Tumors producing a parathyroid hormone-like substance.
- Use of certain medicines such as lithium, tamoxifen, and thiazides.
A lower than normal levels may be due to:
- Disorders that affect absorption of nutrients from the intestines
-
Hypoparathyroidism
(parathyroid glands do not make enough of their hormone)
Hypoparathyroidism
Hypoparathyroidism is a disorder in which the parathyroid glands in the neck do not produce enough parathyroid hormone (PTH).
- Kidney failure
- Low blood level of albumin
- Liver disease
- Magnesium deficiency
- Pancreatitis
- Vitamin D deficiency
Risks
There is very little risk involved with having your blood taken. Veins and arteries vary in size from one person to another and from one side of the body to the other. Taking blood from some people may be more difficult than from others.
Other risks associated with having blood drawn are slight but may include:
- Excessive bleeding
- Fainting or feeling lightheaded
- Hematoma (blood accumulating under the skin)
- Infection (a slight risk any time the skin is broken)
- Multiple punctures to locate veins
References
Dumitru C, Wysolmerski J. Disorders of calcium metabolism. In: Alpern RJ, Moe OW, Caplan M, eds. Seldin and Giebisch's The Kidney . 5th ed. Philadelphia, PA: Elsevier; 2013:chap 66.
Leone KA. Calcium, magnesium, and phosphorus. In: Adams JG, ed. Emergency Medicine: Clinical Essentials . 2nd ed. Philadelphia, PA: Elsevier Saunders; 2013:chap 166.
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Review Date: 11/1/2015
Reviewed By: Laura J. Martin, MD, MPH, ABIM Board Certified in Internal Medicine and Hospice and Palliative Medicine, Atlanta, GA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.