Uric acid - blood
Uric acid is a chemical created when the body breaks down substances called purines. Purines are found in some foods and drinks. These include liver, anchovies, mackerel, dried beans and peas, and beer.
Most uric acid dissolves in blood and travels to the kidneys. From there, it passes out in urine. If your body produces too much uric acid or does not remove enough if it, you can get sick. A high level of uric acid in the blood is called hyperuricemia.
This test checks to see how much uric acid you have in your blood. Another test can be used to check the level of uric acid in your urine .
Uric acid in your urine
The uric acid urine test measures the level of uric acid in urine. Uric acid level can also be checked using a blood test.
How the Test is Performed
A blood sample is needed. Most of the time blood is drawn from a vein located on the inside of the elbow or the back of the hand.
Drawn from a vein
Venipuncture is the collection of blood from a vein. It is most often done for laboratory testing.
How to Prepare for the Test
You should not eat or drink anything for 4 hours before the test unless told otherwise.
Many medicines can interfere with blood test results.
- Your health care provider will tell you if you need to stop taking any medicines before you have this test.
- DO NOT stop or change your medicines without talking to your provider first.
Your provider may also tell you to stop taking any drugs that may affect the test results. Never stop taking any medicine without talking to your provider.
Why the Test is Performed
This test is done to see if you have high levels of uric acid in your blood. High levels of uric acid can sometimes cause gout or kidney disease.
Gout
Gout is a type of arthritis. It occurs when uric acid builds up in blood and causes inflammation in the joints. Acute gout is a painful condition th...
You may have this test if you have had or are about to have certain types of chemotherapy. Rapid weight loss, which may occur with such treatments, can increase the amount of uric acid in your blood.
Normal Results
Normal values range between 3.5 and 7.2 mg/dL.
Normal value ranges may vary slightly among different laboratories. Talk to your provider about the meaning of your specific test results.
The example above shows the common measurement range for results for these tests. Some laboratories use different measurements or may test different specimens.
What Abnormal Results Mean
Greater-than-normal levels of uric acid (hyperuricemia) may be due to:
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Acidosis
Acidosis
Acidosis is a condition in which there is too much acid in the body fluids. It is the opposite of alkalosis (a condition in which there is too much ...
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Alcoholism
Alcoholism
Alcohol use disorder is when your drinking causes serious problems in your life, yet you keep drinking. You may also need more and more alcohol to f...
- Chemotherapy-related side effects
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Diabetes
Diabetes
Diabetes is a chronic disease in which the body cannot regulate the amount of sugar in the blood.
- Excessive exercise
- Gout
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Hypoparathyroidism
Hypoparathyroidism
Hypoparathyroidism is a disorder in which the parathyroid glands in the neck do not produce enough parathyroid hormone (PTH).
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Lead poisoning
Lead poisoning
Lead is a very strong poison. When a person swallows a lead object or breathes in lead dust, some of the poison can stay in the body and cause serio...
- Leukemia
- Medullary cystic kidney disease
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Nephrolithiasis
Nephrolithiasis
A kidney stone is a solid mass made up of tiny crystals. One or more stones can be in the kidney or ureter at the same time.
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Polycythemia vera
Polycythemia vera
Polycythemia vera is a bone marrow disease that leads to an abnormal increase in the number of blood cells. The red blood cells are mostly affected....
- Purine-rich diet
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Renal failure
Renal failure
Acute kidney failure is the rapid (less than 2 days) loss of your kidneys' ability to remove waste and help balance fluids and electrolytes in your b...
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Toxemia of pregnancy
Toxemia of pregnancy
Preeclampsia is when a pregnant woman develops high blood pressure and protein in the urine after the 20th week of pregnancy.
Lower-than-normal levels of uric acid may be due to:
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Fanconi syndrome
Fanconi syndrome
Fanconi syndrome is a disorder of the kidney tubes in which certain substances normally absorbed into the bloodstream by the kidneys are released int...
- Low purine diet
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Syndrome of inappropriate antidiuretic hormone (SIADH) secretion
Syndrome of inappropriate antidiuretic ...
Low sodium level is a condition in which the amount of sodium (salt) in the blood is lower than normal. The medical name of this condition is hypona...
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Wilson disease
Wilson disease
Wilson disease is an inherited disorder in which there is too much copper in the body's tissues. The excess copper damages the liver and nervous sys...
Other reasons this test may be performed include:
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Chronic gouty arthritis
Chronic gouty arthritis
Gout is a type of arthritis. It occurs when uric acid builds up in blood and causes inflammation in the joints. Acute gout is a painful condition th...
- Chronic kidney disease
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Injury of the kidney and ureter
Injury of the kidney and ureter
Injury to the kidney and ureter is damage to the organs of the upper urinary tract.
References
Edwards NL. Crystal deposition diseases. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine . 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 273.
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Blood test - illustration
Blood is drawn from a vein (venipuncture), usually from the inside of the elbow or the back of the hand. A needle is inserted into the vein, and the blood is collected in an air-tight vial or a syringe. Preparation may vary depending on the specific test.
Blood test
illustration
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Uric acid crystals - illustration
These spiked rods are uric acid crystals photographed under polarized light. Increased uric acid blood levels and formation of uric acid crystals in the joints are associated with gout.
Uric acid crystals
illustration
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Blood test - illustration
Blood is drawn from a vein (venipuncture), usually from the inside of the elbow or the back of the hand. A needle is inserted into the vein, and the blood is collected in an air-tight vial or a syringe. Preparation may vary depending on the specific test.
Blood test
illustration
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Uric acid crystals - illustration
These spiked rods are uric acid crystals photographed under polarized light. Increased uric acid blood levels and formation of uric acid crystals in the joints are associated with gout.
Uric acid crystals
illustration
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High blood pressure
(In-Depth)
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Gout
(In-Depth)
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Kidney stones
(In-Depth)
Review Date: 4/30/2015
Reviewed By: Laura J. Martin, MD, MPH, ABIM Board Certified in Internal Medicine and Hospice and Palliative Medicine, Atlanta, GA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.