CO2 blood test
Bicarbonate test; HCO3-; Carbon dioxide test; TCO2; Total CO2; CO2 test - serum
CO2 is carbon dioxide. This article discusses the laboratory test to measures the amount of carbon dioxide in the liquid part of your blood, called the serum.
In the body, most of the CO2 is in the form of a substance called bicarbonate (HCO3-). Therefore, the CO2 blood test is really a measure of your blood bicarbonate level.
How the Test is Performed
A blood sample is needed. Most of the time blood is drawn from a vein located on the inside of the elbow or the back of the hand.
Drawn from a vein
Venipuncture is the collection of blood from a vein. It is most often done for laboratory testing.
How to Prepare for the Test
Many medicines can interfere with blood test results.
- Your health care provider will tell you if you need to stop taking any medicines before you have this test.
- DO NOT stop or change your medicines without talking to your provider first.
How the Test will Feel
You may feel slight pain or a sting when the needle is inserted. You may also feel some throbbing at the site after the blood is drawn.
Why the Test is Performed
The CO2 test is most often done as part of an electrolyte or basic metabolic panel. Changes in your CO2 level may suggest that you are losing or retaining fluid. This may cause an imbalance in your body's electrolytes.
Electrolyte
Electrolytes are minerals in your blood and other body fluids that carry an electric charge. Electrolytes affect how your body functions in many ways...
CO2 levels in the blood are affected by kidney and lung function. The kidneys help maintain the normal bicarbonate levels.
Normal Results
The normal range is 23 to 29 mEq/L (milliequivalents per liter) or 23 to 29 mmol/L.
Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.
The example above shows the common measurement range of results for these tests. Some laboratories use different measurements or may test different specimens.
What Abnormal Results Mean
Abnormal levels may be due to the following problems:
Lower-than-normal levels
-
Addison disease
Addison disease
Addison disease is a disorder that occurs when the adrenal glands do not produce enough hormones.
- Diarrhea
- Ethylene glycol poisoning
-
Ketoacidosis
Ketoacidosis
Diabetic ketoacidosis is a life-threatening problem that affects people with diabetes. It occurs when the body cannot use sugar (glucose) as a fuel ...
- Kidney disease
-
Lactic
acidosis
Acidosis
Acidosis is a condition in which there is too much acid in the body fluids. It is the opposite of alkalosis (a condition in which there is too much ...
-
Metabolic acidosis
Metabolic acidosis
Metabolic acidosis is a condition in which there is too much acid in the body fluids.
- Methanol poisoning
- Salicylate toxicity (such as aspirin overdose)
Higher-than-normal levels
- Breathing disorders
-
Cushing syndrome
Cushing syndrome
Cushing syndrome is a disorder that occurs when your body has a high level of the hormone cortisol.
-
Hyperaldosteronism
Hyperaldosteronism
Hyperaldosteronism is a disorder in which the adrenal gland releases too much of the hormone aldosterone into the blood. Hyperaldosteronism can be pr...
- Vomiting
The following conditions may also alter bicarbonate levels:
-
Alkalosis
Alkalosis
Alkalosis is a condition in which the body fluids have excess base (alkali). This is the opposite of excess acid (acidosis).
-
Delirium
Delirium
Delirium is sudden severe confusion due to rapid changes in brain function that occur with physical or mental illness.
-
Dementia
Dementia
Dementia is a loss of brain function that occurs with certain diseases. It affects memory, thinking, language, judgment, and behavior.
-
Renal tubular acidosis; distal
Renal tubular acidosis; distal
Distal renal tubular acidosis is a disease that occurs when the kidneys do not properly remove acids from the blood into the urine. As a result, too...
-
Renal tubular acidosis; proximal
Renal tubular acidosis; proximal
Proximal renal tubular acidosis is a disease that occurs when the kidneys don't properly remove acids from the blood into the urine. As a result, to...
References
Seifter JL. Acid-base disorders. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine . 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 118.
Review Date: 4/30/2015
Reviewed By: Laura J. Martin, MD, MPH, ABIM Board Certified in Internal Medicine and Hospice and Palliative Medicine, Atlanta, GA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.