Salivary gland tumors
Tumor - salivary duct
Salivary gland tumors are abnormal cells growing in the gland or in the tubes (ducts) that drain the salivary glands.
Causes
The salivary glands are located around the mouth. They produce saliva, which moistens food to help with chewing and swallowing.
There are 3 main pairs of salivary glands. The parotid glands are the largest. They are located in each cheek in front of the ears. Two submandibular glands are under the floor of the mouth under both sides of the jaw. Two sublingual glands are under the floor of the mouth. There are also thousands of small salivary glands lining the rest of the mouth.
Salivary glands empty saliva into the mouth through ducts that open at various places in the mouth.
Salivary gland tumors are rare. Swelling of the salivary glands is mostly due to:
- Abdominal surgery
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Cirrhosis of the liver
Cirrhosis of the liver
Cirrhosis is scarring of the liver and poor liver function. It is the last stage of chronic liver disease.
- Infections
-
Other
cancers
Cancers
A tumor is an abnormal growth of body tissue. Tumors can be cancerous (malignant) or noncancerous (benign).
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Salivary duct stones
Salivary duct stones
Salivary duct stones are deposits of minerals in the ducts that drain the salivary glands. Salivary duct stones are a type of salivary gland disorde...
-
Salivary gland infections
Salivary gland infections
Salivary gland infections affect the glands that produce spit (saliva). The infection may be due to bacteria or viruses. There are 3 pairs of major ...
- Dehydration
-
Sarcoidosis
Sarcoidosis
Sarcoidosis is a disease in which inflammation occurs in the lymph nodes, lungs, liver, eyes, skin, or other tissues.
-
Sjögren syndrome
Sjögren syndrome
Sjögren syndrome is an autoimmune disorder in which the glands that produce tears and saliva are destroyed. This causes dry mouth and dry eyes. The...
The most common type of salivary gland tumor is a slow-growing noncancerous (benign) tumor of the parotid gland. The tumor gradually increases the size of the gland. Some of these tumors can be cancerous (malignant).
Symptoms
Symptoms may include any of the following:
- Firm, usually painless swelling in one of the salivary glands (in front of the ears, under the chin, or on the floor of the mouth). The swelling gradually increases.
- Difficulty moving one side of the face, known as facial nerve palsy.
Exams and Tests
An examination by a health care provider or dentist shows a larger than normal salivary gland, usually one of the parotid glands.
Tests may include:
- X-rays of the salivary gland (called a ptyalogram or sialogram) to look for a tumor
-
Ultrasound
,
CT scan
or
MRI
to confirm that there is a growth, and to see if the cancer has spread to lymph nodes in the neck
Ultrasound
Ultrasound uses high-frequency sound waves to make images of organs and structures inside the body.
CT scan
A computed tomography (CT) scan is an imaging method that uses x-rays to create pictures of cross-sections of the body. Related tests include:Abdomin...
MRI
A magnetic resonance imaging (MRI) scan is an imaging test that uses powerful magnets and radio waves to create pictures of the body. It does not us...
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Salivary gland biopsy
or fine needle aspiration to determine whether the tumor is benign (noncancerous) or malignant (cancerous)
Salivary gland biopsy
Salivary gland biopsy is the removal of cells or a piece of tissue from a salivary gland for exam.
Treatment
Surgery is most often done to remove the affected salivary gland. If the tumor is benign, no other treatment is needed.
Radiation therapy or extensive surgery may be needed if the tumor is cancerous. Chemotherapy may be used when the disease has spread beyond the salivary glands.
Radiation therapy
Radiation therapy uses high-powered x-rays, particles, or radioactive seeds to kill cancer cells.
Chemotherapy
The term chemotherapy is used to describe cancer-killing drugs. Chemotherapy may be used to:Cure the cancerShrink the cancerPrevent the cancer from ...
Outlook (Prognosis)
Most salivary gland tumors are noncancerous and slow growing. Removing the tumor with surgery often cures the condition. In rare cases, the tumor is cancerous and further treatment is needed.
Possible Complications
Complications from the cancer or its treatment may include:
- Spread of the cancer to other organs (metastasis).
- In rare cases, injury during surgery to the nerve that controls movement of the face.
When to Contact a Medical Professional
Call your provider if:
- You have pain when eating or chewing
- You notice a lump in the mouth, under the jaw, or in the neck that does not go away in 2 to 3 weeks or is getting larger
References
National Cancer Institute. PDQ salivary gland cancer treatment. Bethesda, MD: National Cancer Institute. Last modified September 25, 2015. www.cancer.gov/cancertopics/pdq/treatment/salivarygland/HealthProfessional . Accessed February 22, 2016
National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology (NCCN guidelines): Head and neck cancers. Version 1.2015. www.nccn.org/professionals/physician_gls/pdf/head-and-neck.pdf . Accessed February 22, 2016.
Saade RE, Bell DM, Hanna EY. Benign neoplasms of the salivary glands. In: Flint PW, Haughey BH, Lund V, et al, eds. Cummings Otolaryngology: Head & Neck Surgery . 6th ed. Philadelphia, PA: Elsevier Saunders; 2015:chap 86.
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Head and neck glands - illustration
There are several pairs of salivary glands in different locations: a major pair in front of the ears (parotid glands); two major pairs on the floor of the mouth (sublingual and submaxillary glands); and several minor pairs within the lips, cheeks, and tongue.
Head and neck glands
illustration
-
Head and neck glands - illustration
There are several pairs of salivary glands in different locations: a major pair in front of the ears (parotid glands); two major pairs on the floor of the mouth (sublingual and submaxillary glands); and several minor pairs within the lips, cheeks, and tongue.
Head and neck glands
illustration
Review Date: 10/30/2015
Reviewed By: Sumana Jothi, MD, specialist in laryngology, Clinical Instructor UCSF Otolaryngology, NCHCS VA, SFVA, San Francisco, CA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.