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Factor XII (Hageman factor) deficiency
Factor XII deficiency is an inherited disorder that affects a protein (factor XII) involved in blood clotting.
Causes
When you bleed, a series of reactions take place in the body that helps blood clots form. This process is called the coagulation cascade. It involves special proteins called coagulation, or clotting, factors. You may have a higher chance of excess bleeding if one or more of these factors are missing or are not functioning like they should.
Factor XII is one such factor. A lack of this factor does not cause you to bleed abnormally. But, the blood takes longer than normal to clot in a test tube.
Factor XII deficiency is a rare inherited disorder.
Symptoms
There are usually no symptoms.
Exams and Tests
Factor XII deficiency is most often found when clotting tests are done for routine screening.
Tests may include:
-
Factor XII assay
Factor XII assay
The factor XII assay is a blood test to measure the activity of factor XII. This is one of the proteins in the body that helps the blood clot....
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Partial thromboplastin time (
PTT
)
PTT
Partial thromboplastin time (PTT) is a blood test that looks at how long it takes for blood to clot. It can help tell if you have a bleeding problem...
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Treatment
Treatment is usually not needed.
Outlook (Prognosis)
The outcome is expected to be good without treatment.
Possible Complications
There are usually no complications.
When to Contact a Medical Professional
The health care provider usually discovers this condition when running other lab tests.
Prevention
This is an inherited disorder. There is no known way to prevent it.
References
Gailani D, Neff AT. Rare coagulation factor deficiencies. In: Hoffman R, Benz EJ Jr, Silberstein LE, Heslop HE, Weitz JI, Anastasi JI, eds. Hematology: Basic Principles and Practice . 6th ed. Philadelphia, PA: Elsevier Saunders; 2012:chap 139.
Ragni MV. Hemorrhagic disorders: coagulation deficiencies. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine. 24th ed. Philadelphia, PA: Elsevier Saunders; 2012:chap 177.
Review Date: 1/22/2015
Reviewed By: Rita Nanda, MD, assistant professor of medicine, section of hematology/oncology, University of Chicago Medicine, Chicago, IL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.
