Osimertinib (By mouth)

There may be other brand names for this medicine.

This medicine is not right for everyone. Do not use it if you had an allergic reaction to osimertinib, or if you are pregnant or breastfeeding.

Your doctor will tell you how much medicine to use. Do not use more than directed.
If you cannot swallow the tablet, put it in a glass with 2 ounces of water. Do not use carbonated water or other liquids. Stir until the tablet is in small pieces, and drink the mixture right away. Add 4 to 8 ounces of water to the same glass, and drink it to make sure you get the full dose.
Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
Missed dose: Skip the missed dose, and then go back to your regular schedule. Do not take extra medicine to make up for a missed dose.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Some medicines can affect how osimertinib works. Tell your doctor if you are using carbamazepine, phenytoin, rifampicin, rosuvastatin, St John's wort, sulfasalazine, or topotecan.

This medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant. Women should use effective birth control during treatment and for at least 6 weeks after the last dose. Men should use effective birth control during treatment and for at least 4 months after the last dose.
Do not breastfeed while you are taking this medicine and for 2 weeks after your last dose.
Tell your doctor if you have heart disease, heart failure, heart rhythm problems (including QT prolongation), or a history of other lung disease or breathing problems.
This medicine may cause the following problems:
- Interstitial lung disease or pneumonitis
- Heart rhythm changes
- Heart problems, including heart failure
This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Keep all medicine out of the reach of children. Never share your medicine with anyone.

Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Fast, slow, pounding, or uneven heartbeat
Lightheadedness, dizziness, fainting
Swelling in your hands, ankles, or feet
Trouble breathing, chest pain, fever, chills, cough

Last Updated: 1/27/2017