Alogliptin/pioglitazone (By mouth)

There may be other brand names for this medicine.

This medicine is not right for everyone. Do not use it if you had an allergic reaction to alogliptin or pioglitazone.

Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
Swallow the tablet whole. Do not split, crush, break, or chew it.
This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Some medicines can affect how alogliptin/pioglitazone works. Tell your doctor if you are using gemfibrozil, rifampin, or another diabetes medicine (including insulin).

Tell your doctor if you are pregnant or breastfeeding. If you had problems ovulating or have irregular periods, this medicine may cause you to ovulate, which could lead to pregnancy if you are sexually active. Talk to your doctor about effective birth control while you are using this medicine.
Tell your doctor if you have kidney disease, liver disease, heart failure, edema (fluid retention or swelling), macular edema (swelling of the back of the eye), bone problems, or a history of bladder cancer or pancreas problems.
This medicine may cause the following problems:
- Heart failure
- Pancreatitis
- Liver damage
- Increased risk for broken bones
- Increased risk for bladder cancer if you use this medicine for a long time
- Low blood sugar levels
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Keep all medicine out of the reach of children. Never share your medicine with anyone.

Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Blistering, peeling, or red skin rash
Blurred vision or other vision changes
Change in how much or how often you urinate, painful urination, lower back or side pain, blood in your urine
Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
Rapid weight gain, swelling in your hands, ankles, or feet, trouble breathing, tiredness
Severe joint pain
Shaking, trembling, sweating, fast or pounding heartbeat, faintness, hunger, confusion
Sudden and severe stomach pain, nausea, vomiting, fever, lightheadedness

Last Updated: 1/27/2017