Cabozantinib (By mouth)

There may be other brand names for this medicine.

This medicine is not right for everyone. Do not use it if you had an allergic reaction to cabozantinib, or if you are pregnant.

Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
Your doctor will tell you how much medicine to use. Do not use more than directed.
Do not substitute the tablets with the capsules .
It is best to take this medicine on an empty stomach. Do not eat for at least 2 hours before and 1 hour after you take this medicine.
Swallow the medicine whole with at least 8 ounces of water. Do not crush, break, chew, or open the medicine.
Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
Missed dose:
- Less than 12 hours until your next scheduled dose: Skip the missed dose and take your next dose at the normal time. Do not take extra medicine to make up for the missed dose.
- More than 12 hours until your next dose: Take a dose as soon as you can. Then take your next dose at the scheduled time.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Some foods and medicines can affect how cabozantinib works. Tell your doctor if you are using abacavir, adefovir, atazanavir, boceprevir, carbamazepine, cidofovir, clarithromycin, conivaptan, dexamethasone, furosemide, indinavir, itraconazole, ketoconazole, lamivudine, lopinavir, nefazodone, nelfinavir, nevirapine, phenobarbital, phenytoin, posaconazole, probenecid, rifabutin, rifampin, rifapentine, ritonavir, saquinavir, St John's wort, telithromycin, tenofovir, or voriconazole.
Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. Use birth control for at least 4 months after you stop using this medicine.
Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, blood clotting or bleeding problems, high blood pressure, an open wound, or dental problems.
This medicine may cause the following problems:
- Severe bleeding problems
- High blood pressure, heart attack, stroke, or blood clot
- Higher levels of protein in your urine, which may lead to kidney damage
- Hand-foot skin reaction, a condition that can cause pain and blisters on your hands or feet
- Perforation (hole) or fistula in your digestive system
- Jaw bone problems that can cause pain or sores to develop in your mouth
- Reversible posterior leukoencephalopathy syndrome (RPLS, a central nervous system disorder)
This medicine may cause you to bleed more easily and cause wounds to heal slowly. Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.
Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
Keep all medicine out of the reach of children. Never share your medicine with anyone.

Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Chest pain that may spread to your arms, jaw, back, or neck, trouble breathing, nausea, unusual sweating, fainting
Gagging, coughing, or choking when you eat or drink
Numbness or weakness on one side of your body, sudden or severe headache, seizure, confusion, problems with vision, speech, or walking
Rash, redness, pain, swelling, or blisters on the palms of your hands or soles of your feet
Red or dark brown urine, bloody or black, tarry stools, unexplained nosebleeds, vomit that looks like coffee grounds
Severe diarrhea or stomach pain
Severe pain
Swelling in your hands, arms, legs, or feet
Tightness in your jaw, mouth pain or numbness, loose teeth
Unusual or heavy bleeding, bruising, or weakness

Last Updated: 1/27/2017