Axitinib (By mouth)

There may be other brand names for this medicine.

This medicine is not right for everyone. Do not use it if you had an allergic reaction to axitinib or you are pregnant.

Take your medicine as directed. Your dose may need to be changed several times to find what works best for you. Take each dose 12 hours apart.
Swallow the tablet whole with a glass of water. Do not break, crush, or chew it.
Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
Missed dose: This medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor for instructions.
If you vomit after you take the medicine, do not take more. Just take your next dose at the regular time.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Some foods and medicines can affect how axitinib works. Tell your doctor if you are using any of the following:
- Bosentan, dexamethasone, modafinil, nafcillin, nefazodone, St John's wort
- HIV/AIDS medicine, such as atazanavir, efavirenz, etravirine, indinavir, nelfinavir, ritonavir, saquinavir
- Infection medicine, such as clarithromycin, itraconazole, ketoconazole, telithromycin, voriconazole
- Seizure medicine, such as carbamazepine, phenobarbital, phenytoin
- Tuberculosis medicine, such as rifabutin, rifampin, rifapentine
Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

This medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant.
Tell your doctor if you are breastfeeding, or if you have liver disease, high blood pressure, thyroid problems, or a history of a heart attack, heart failure, stroke, or blood clotting problems.
This medicine may cause the following problems:
- High blood pressure
- Bleeding problems or blood clots
- Heart failure
- Tears or holes in your stomach or bowel
- Thyroid changes
- Reversible posterior leukoencephalopathy syndrome (RPLS)
Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.
Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
Cancer medicine can cause nausea or vomiting, sometimes even after you receive medicine to prevent these effects. Ask your doctor or nurse about other ways to control any nausea or vomiting that might happen.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Keep all medicine out of the reach of children. Never share your medicine with anyone.

Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Chest pain, trouble breathing, coughing up blood
Fast, slow, or pounding heartbeat
Numbness or weakness on one side of your body, sudden or severe headache, pain in your calf, problems with vision, speech, or walking
Red or brown urine, bloody or black stools, vomiting blood
Redness, pain, swelling, or blisters on the palms of your hands or soles of your feet
Seizure, headache, confusion, trouble seeing
Severe or ongoing stomach pain
Swelling in your hands, ankles, or feet
Tiredness, feeling too hot or cold, hair loss, weight gain, or voice changes
Unusual bleeding, bruising, tiredness, or weakness

Last Updated: 1/27/2017