Aliskiren/amlodipine (By mouth)

There may be other brand names for this medicine.

This medicine is not right for everyone. Do not use if you had an allergic reaction to aliskiren or amlodipine, or if you are pregnant.

Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
Take this medicine the same way and at the same time every day. Take it routinely with or without food. Do not take with a high-fat meal.
Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Do not use this medicine if you have diabetes and also take another blood pressure medicine (ACE inhibitor or ARB). Do not use this medicine together with cyclosporine or itraconazole.
Some foods and medicines can affect how aliskiren works. Tell your doctor if you are also using any of the following:
- Diuretic (water pill, such as furosemide)
- NSAID pain or arthritis medicine (such as aspirin, diclofenac, ibuprofen, naproxen, celecoxib)
- Ketoconazole
- Simvastatin
- Medicine to treat HIV/AIDS (such as indinavir, ritonavir).
- Potassium in any medicine, supplement, or salt substitute

It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
Tell your doctor if you are breastfeeding or if you have kidney problems, liver disease, heart or blood vessel disease (including heart failure or a history of a heart attack), diabetes, or low blood pressure.
This medicine may cause the following problems:
- Higher risk of heart attack or increased angina (severe chest pain)
- Kidney problems
This medicine could lower your blood pressure too much when you first use it or if you are dehydrated. Stand or sit up slowly if you feel lightheaded or dizzy.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Keep all medicine out of the reach of children. Never share your medicine with anyone.

Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Chest pain that may spread to your arms, jaw, back, or neck, trouble breathing, nausea, unusual sweating, or faintness
Confusion, weakness, uneven heartbeat, trouble breathing, or numbness or tingling in your hands, feet, or lips
Decrease in how much or how often you urinate
Lightheadedness, dizziness, or fainting
Rapid weight gain, swelling in your hands, ankles, or feet

Last Updated: 1/27/2017