Aprotinin/calcium chloride/fibrinogen/thrombin (On the skin)

Controls bleeding during surgery.

Brand Name(s):

Artiss

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not receive this medicine if you have had an allergic reaction to aprotinin, calcium chloride, fibrinogen, thrombin, or bovine proteins (from animals such as oxen or cows).

How to Use This Medicine:

Solution

A nurse or other trained health professional will give you this medicine.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Warnings While Using This Medicine:

Make sure your doctor knows if you are pregnant or breastfeeding.
This medicine is made from donated human blood. Some human blood products have transmitted certain viruses to people who have received them. The risk of getting a virus from human blood products has been greatly reduced because all donated blood must be tested before any products are made. Talk with your doctor if you have any concerns about this risk.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Fast or slow heartbeat.
Fever or chills.
Joint pain.
Lightheadedness or fainting.
Nausea.
Skin rash.
Warmth or redness in your face, neck, arms, or upper chest.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 1/27/2017