Erlotinib (By mouth)

There may be other brand names for this medicine.

This medicine is not right for everyone. Do not use it if you had an allergic reaction to erlotinib or if you are pregnant.

Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
It is best to take this medicine on an empty stomach. Take the medicine at least 1 hour before or 2 hours after you eat.
Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Some foods and medicines can affect how erlotinib works. Tell your doctor if you are using any of the following:
- Boceprevir, carbamazepine, ciprofloxacin, clarithromycin, conivaptan, indinavir, itraconazole, ketoconazole, lopinavir/ritonavir, nefazodone, nelfinavir, phenobarbital, phenytoin, posaconazole, rifabutin, rifampin, rifapentine, ritonavir, saquinavir, St John's wort, telithromycin, teriflunomide, or voriconazole
- Blood thinner (including warfarin)
- Other cancer medicines
- NSAID pain or arthritis medicine (including aspirin, diclofenac, ibuprofen, naproxen)
- Steroid medicine (including hydrocortisone, methylprednisolone, prednisolone, prednisone)
Tell your doctor if you take any stomach medicine, including omeprazole, ranitidine, or an antacid. Some stomach medicines need to be taken several hours before or after you take erlotinib.
Do not eat grapefruit or drink grapefruit juice while you are using this medicine.
Tell your doctor if you change how much or how often you smoke, or if you quit smoking. Your treatment might need to be changed.

It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. You should continue to use birth control during treatment and for 1 month after you have stopped taking this medicine.
Do not breastfeed during treatment and for 2 weeks after your last dose of this medicine.
Tell your doctor if you have kidney disease, liver disease, bleeding problems, eye or vision problems, stomach problems (such as ulcers or diverticulosis), or a history of other lung disease, heart attack, or stroke.
Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
This medicine may cause the following problems:
- Lung problems
- Bleeding or perforation in your digestive system
- Liver problems
- Kidney problems
- Eye problems
Cancer medicines can cause severe diarrhea, nausea, or vomiting. Ask your doctor about ways to control these side effects.
This medicine may cause a rash or other skin problems. You may use alcohol-free emollient creams or sunscreen to help prevent this. Stay out of the sun when possible.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Keep all medicine out of the reach of children. Never share your medicine with anyone.

Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Blistering, peeling, red skin rash
Bloody or black, tarry stools, vomiting material that looks like coffee grounds
Chest pain that may spread, unusual sweating, faintness
Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
Decrease in how much or how often you urinate
Eye redness, irritation, or pain
Fever, chills, cough, sore throat, and body aches
Numbness or weakness on one side of your body, sudden or severe headache, problems with vision, speech, or walking
Severe diarrhea, nausea, or vomiting
Tiny red dots on the skin, especially on the lower legs
Unusual bleeding, bruising, or weakness
Unusual trouble breathing, fever, cough

Last Updated: 1/27/2017