Main Campus: Chesterfield, MO 63017 | 
Papain/urea/chlorophyllin copper (On the skin)
Chlorophyllin Copper Complex (klor-oh-FIL-in KOP-per kom-plex), Papain (pa-PAY-in), Urea (ure-EE-a)
Treats many kinds of skin sores and infections, including burns, bed sores, wounds from surgery, and skin ulcers caused by diabetes or varicose veins.
Brand Name(s):
There may be other brand names for this medicine.When This Medicine Should Not Be Used:
You should not use this medicine if you have had an allergic reaction to papain, papaya fruit, urea, or chlorophyllin copper.How to Use This Medicine:
Spray, Ointment, Liquid Under Pressure
- Your doctor will tell you how much medicine to use. Do not use more than directed.
- Use this medicine only on your skin. Rinse it off right away if it gets on a cut or scrape. Do not get the medicine in your eyes, nose, or mouth.
- Wash your hands with soap and water before and after you use this medicine.
- Clean the affected skin area just before using this medicine. A nurse or other health caregiver will show you what to use and how to clean your wound. Do not use hydrogen peroxide to clean your wound.
- Apply a thin layer of ointment to the affected area. Cover the area as directed.
- Before using a new spray bottle, prime the pump by holding the spray upright directly over the wound, and pumping 6 to 8 times.
- Once the spray pump has been primed, hold the bottle about 2 to 3 inches from your wound to apply. Use even, firm, and equal pressure each time you pump the bottle. Completely cover your wound site with the medicine. You should not be able to see the wound under the medicine. Then, follow your doctor's directions for dressing (covering) the wound.
If a dose is missed:
- Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
How to Store and Dispose of This Medicine:
- Store this medicine at room temperature, away from heat and direct light. Keep the container opening covered and clean when you are not using it. Store the spray upright.
- Ask your pharmacist or doctor how to dispose of the medicine container and any leftover or expired medicine.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Do not use any medicine that contains lead, silver, or mercury on your wound. Do not use cosmetics or other skin care products on the treated skin areas.
Warnings While Using This Medicine:
- Make sure your doctor knows if you are pregnant or breastfeeding.
- Do not use this medicine to treat a skin problem your doctor has not examined.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
If you notice these less serious side effects, talk with your doctor:
- Burning, redness, or irritation of the treated skin.
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Last Updated: 1/27/2017
