Selegiline (By mouth)

There may be other brand names for this medicine.

This medicine is not right for everyone. Do not use it if you had an allergic reaction to selegiline.

Your doctor will tell you how much medicine to use. Do not use more than directed.
Capsules or tablets: Take at breakfast and lunch.
Disintegrating tablet: It is best to take the tablet before breakfast. Do not eat or drink anything for 5 minutes before and after you take the tablet. Do not open the blister pack until you are ready to take your medicine. Peel back the foil to remove the tablet. Do not push the tablet through the foil. Place the tablet on your tongue and wait for it to melt.
Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

You must avoid many other medicines while you are using selegiline. These medicines used together could cause serious health problems, including death. Ask your doctor before you use any other medicine. You may need to wait 1 to 5 weeks before you can use the other medicine.
Do not use selegiline if you are also using cyclobenzaprine, dextromethorphan, meperidine, methadone, propoxyphene, St John's wort, or tramadol. Do not use this medicine if you have used another MAO inhibitor within the past 14 days.
Some other medicines that may interact with selegiline include carbamazepine, nafcillin, phenobarbital, phenytoin, rifampin, cough and cold medicine (such as dextromethorphan, ephedrine), or medicine to treat depression or mental health problems. This is not a complete list.
Avoid foods and drinks that are high in tyramine, because your blood pressure could get dangerously high. Your doctor should give you a complete list. In general, do not eat anything aged or fermented, such as most cheese, most alcohol, cured meat (such as salami), sauerkraut, and soy sauce. Check the expiration dates on packages. Tyramine levels get higher as food gets older or if it has not been refrigerated properly.

Tell your doctor if you are pregnant or breastfeeding, or if you have kidney problems, liver problems, dyskinesia, high blood pressure, or a history of mental health problems. Tell your doctor if you have phenylketonuria (PKU).
This medicine may cause the following problems:
- High or low blood pressure
- Serotonin syndrome (when used with other medicines)
- Dyskinesia (trouble controlling movements)
- Unusual changes in behavior, compulsive behavior, hallucinations
- Increased risk of skin cancer
This medicine may make you drowsy. It may even cause you to fall asleep without warning while you are driving or doing other activities. Do not drive or do anything that could be dangerous until you know how this medicine affects you. Stand up slowly if you feel dizzy or lightheaded.
Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
Keep all medicine out of the reach of children. Never share your medicine with anyone.

Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Anxiety, restlessness, fever, sweating, nausea, vomiting, diarrhea, seeing or hearing things that are not there
Chest pain, fast, slow, or uneven heartbeat, severe headache
Confusion, unusual changes in mood or behavior, behaviors you cannot control
Lightheadedness, dizziness, fainting
Muscle spasms, twitching, uncontrolled movements (especially of the face, neck, or back)
Unusual drowsiness or sleepiness

Last Updated: 1/27/2017