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Gangrene

 

Gangrene is the death of tissue in part of the body.

Causes

Gangrene happens when a body part loses its blood supply. This may happen from injury, an infection, or other causes. You have a higher risk for gangrene if you have:

  • A serious injury
  • Blood vessel disease (such as arteriosclerosis, also called hardening of the arteries, in your arms or legs)
  • Diabetes
  • Suppressed immune system (for example, from HIV or chemotherapy)
  • Surgery

Symptoms

 

The symptoms depend on the location and cause of the gangrene. If the skin is involved, or the gangrene is close to the skin, the symptoms may include:

  • Discoloration (blue or black if skin is affected; red or bronze if the affected area is beneath the skin)
  • Foul-smelling discharge
  • Loss of feeling in the area (which may happen after severe pain in the area)

If the affected area is inside the body (such as gangrene of the gallbladder or gas gangrene ), the symptoms may include:

  • Confusion
  • Fever
  • Gas in tissues beneath the skin
  • General ill feeling
  • Low blood pressure
  • Persistent or severe pain

 

Exams and Tests

 

The doctor may diagnose gangrene from a physical examination. In addition, the following tests and procedures may be used to diagnose gangrene:

  • Arteriogram (special x-ray to see any blockages in the blood vessels) to help plan treatment for blood vessel disease
  • Blood tests (white blood cell [WBC] count may be high)
  • CT scan to examine internal organs
  • Culture of the tissue or fluid from wounds to identify bacterial infection
  • Examining tissue under the microscope to look for cell death
  • X-rays

 

Treatment

 

Gangrene requires urgent evaluation and treatment. In general, dead tissue should be removed to allow healing of the surrounding living tissue and prevent further infection. Depending on the area that has the gangrene, the person's overall condition, and the cause of the gangrene, treatment may include:

  • Amputating the body part that has gangrene
  • An emergency operation to find and remove dead tissue
  • An operation to improve blood supply to the area
  • Antibiotics
  • Repeated operations to remove dead tissue (debridement)
  • Treatment in the intensive care unit (for severely ill patients)

 

Outlook (Prognosis)

 

What to expect depends on where the gangrene is in the body, how much gangrene there is, and the person's overall condition. If treatment is delayed, the gangrene is extensive, or the person has other significant medical problems, the person may die.

 

Possible Complications

 

Complications depend on where in the body the gangrene is, how much gangrene there is, the cause of the gangrene, and the person's overall condition. Complications can include:

  • Disability from amputation or removal of dead tissue
  • Prolonged wound healing or the need for reconstructive surgery, such as skin grafting

 

When to Contact a Medical Professional

 

Call your doctor right away if:

  • A wound does not heal or there are frequent sores in an area
  • An area of your skin turns blue or black
  • There is foul-smelling discharge from any wound on your body
  • You have persistent, unexplained pain in an area
  • You have persistent, unexplained fever

 

Prevention

 

Gangrene may be prevented if it is treated before the tissue damage is irreversible. Wounds should be treated properly and watched carefully for signs of infection (such as spreading redness, swelling, or drainage) or failure to heal.

People with diabetes or blood vessel disease should routinely examine their feet for any signs of injury, infection, or change in skin color and seek care as needed.

 

 

References

Kumar V, Abbas AK, Aster JC. Cellular responses to stress and toxic insults. In: Kumar V, Abbas AK, Aster JC, eds. Robbins and Cotran Pathologic Basis of Disease . 9th ed. Philadelphia, PA: Elsevier Saunders; 2015:chap 2.

Lewandowski L, Caruso J, Fleming ME. Gangrene of the foot. In: Cameron JL, Cameron AM, eds. Current Surgical Therapy . 11th ed. Philadelphia, PA: Elsevier Saunders; 2014:931-936.

 
  • Gangrene - illustration

    Gangrene is the death of tissue in part of the body. Gangrene can occur when a body part loses its blood supply. This may happen from, for example, injury or infection.

    Gangrene

    illustration

    • Gangrene - illustration

      Gangrene is the death of tissue in part of the body. Gangrene can occur when a body part loses its blood supply. This may happen from, for example, injury or infection.

      Gangrene

      illustration


     

    Review Date: 9/10/2015

    Reviewed By: Jatin M. Vyas, MD, PhD, Assistant Professor in Medicine, Harvard Medical School; Assistant in Medicine, Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, MA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.

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