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B-cell leukemia/lymphoma panel
B lymphocyte cell surface markerspasting; Flow cytometry - leukemia/lymphoma immunophenotyping
B-cell leukemia/lymphoma panel is a blood test that looks for certain proteins on the surface of white blood cells called B-lymphocytes. The proteins are markers that may help diagnose leukemia or lymphoma.
Leukemia
Leukemia is a type of blood cancer that begins in the bone marrow. Bone marrow is the soft tissue in the center of the bones, where blood cells are ...
How the Test is Performed
A blood sample is needed.
Blood sample
Venipuncture is the collection of blood from a vein. It is most often done for laboratory testing.
In some cases, white blood cells are removed during a bone marrow biopsy . The sample may also be taken during a lymph node biopsy or other biopsy when lymphoma is suspected.
Bone marrow biopsy
A bone marrow biopsy is the removal of marrow from inside bone. Bone marrow is the soft tissue inside bones that helps form blood cells. It is foun...
Lymph node biopsy
A lymph node biopsy is the removal of lymph node tissue for examination under a microscope. The lymph nodes are small glands that make white blood ce...
The blood sample is sent to a laboratory, where a specialist checks the cell type and characteristics. This procedure is called immunophenotyping. The test is usually done using a technique called flow cytometry.
How to Prepare for the Test
No special preparation is usually necessary.
How the Test will Feel
When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or a slight bruise. This soon goes away.
Why the Test is Performed
This test may be done for the following reasons:
-
When other tests (such as a
blood smear
) show signs of abnormal white blood cells
Blood smear
A blood smear is a blood test that gives information about the number and shape of blood cells. It is often done as part of or along with a complete...
ImageRead Article Now Book Mark Article - When leukemia or lymphoma is suspected
- To find out the type of leukemia or lymphoma
What Abnormal Results Mean
Abnormal results usually indicate either:
-
B-cell
lymphocytic leukemia
Lymphocytic leukemia
Acute lymphoblastic leukemia (ALL) is a fast-growing cancer of a type of white blood cell called a lymphoblast. ALL occurs when the bone marrow prod...
ImageRead Article Now Book Mark Article - Lymphoma
Risks
Veins and arteries vary in size from one person to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.
Other risks associated with having blood drawn are slight, but may include:
- Excessive bleeding
- Fainting or feeling lightheaded
- Hematoma (blood accumulating under the skin)
- Infection (a slight risk any time the skin is broken)
References
Appelbaum FR. The acute leukemias. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine . 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 183.
Bierman PJ, Armitage JO. Non-Hodgkin lymphomas. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine . 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 185.
Borowitz MJ. Flow cytometry in oncologic diagnosis. In: Niederhuber JE, Armitage JO, Doroshow JH, Kastan MB, Tepper JE, eds. Abeloff's Clinical Oncology . 5th ed. Philadelphia, PA: Elsevier Saunders; 2014:chap 15.
Connors JM. Hodgkin lymphoma. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine . 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 186.
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Blood test - illustration
Blood is drawn from a vein (venipuncture), usually from the inside of the elbow or the back of the hand. A needle is inserted into the vein, and the blood is collected in an air-tight vial or a syringe. Preparation may vary depending on the specific test.
Blood test
illustration
-
Blood test - illustration
Blood is drawn from a vein (venipuncture), usually from the inside of the elbow or the back of the hand. A needle is inserted into the vein, and the blood is collected in an air-tight vial or a syringe. Preparation may vary depending on the specific test.
Blood test
illustration
Review Date: 2/11/2016
Reviewed By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.
