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    Allergic vasculitis

    Vasculitis - allergic; Hypersensitivity vasculitis; Cutaneous leukocytoclastic vasculitis

    Allergic vasculitis is an extreme reaction to a drug, infection, or foreign substance. It leads to inflammation and damage to blood vessels of the skin.

    Causes

    Allergic vasculitis is caused by an allergic reaction to a drug, an infection,or other foreign substance. It most often affects people older than age 15.

    Often, the cause of the problem cannot be found even with a careful medical history.

    Allerigic vasculitis may look like necrotizing vasculitis, which can affect blood vessels around the body.

    Symptoms

    • Purple-colored spots and patches on the skin
    • Skin sores mostly located on the legs, buttocks, or trunk
    • Blisters on the skin
    • Hives (urticaria), may last longer than 24 hours
    • Open sores with dead tissue (necrotic ulcers)

    Exams and Tests

    The doctor will base the diagnosis on symptoms and the appearance of how your skin looks after you take a certain medicine or are exposed to a foreign substance (antigen).

    Results from an ESR test may be high. Skin biopsy shows inflammation of the small blood vessels. You may also have other tests to detect this condition.

    Treatment

    The goal of treatment is to reduce inflammation.

    Your health care provider may prescribe aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs),or corticosteroids to reduce inflammation of the blood vessels. (DO NOT give aspirin to children except as advised by your health care provider.)

    Your doctor may tell you to stop takinga medicine that could be causing this condition. Do not stop taking any medicine without first talking to your doctor.

    Outlook (Prognosis)

    Allergic vasculitis usually goes away over time. The condition may come back in some people.

    People with ongoing vasculitis should be checked for necrotizing vasculitis.

    Possible Complications

    • Lasting damage to the blood vessels or skin with scarring
    • Inflammation of the blood vessels affects the internal organs

    When to Contact a Medical Professional

    Call your health care provider if you have symptoms of allergic vasculitis.

    Prevention

    Do not take medicines which have caused an allergic reaction in the past.

    References

    Stone JH. Immune complex-mediated small vessel vasculitis. In: Firestein GS, Budd RC, Gabriel SE, et al, eds. Kelley's Textbook of Rheumatology. 9th ed. Philadelphia, Pa: Saunders Elsevier; 2012:chap 91.

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    • Vasculitis

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      A Closer Look

        Talking to your MD

          Self Care

            Tests for Allergic vasculitis

              Review Date: 4/20/2013

              Reviewed By: Gordon A. Starkebaum, MD, Professor of Medicine, Division of Rheumatology, University of Washington School of Medicine. Also reviewed by A.D.A.M. Health Solutions, Ebix, Inc., Editorial Team: David Zieve, MD, MHA, Bethanne Black, Stephanie Slon, and Nissi Wang.

              The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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