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    Hemolytic anemia caused by chemicals and toxins

    Anemia - hemolytic - caused by chemicals or toxins

    Hemolytic anemia caused by chemicals and toxins is a lack of red blood cells that occurs when red blood cells are excessively damaged bycertain chemicals or toxins.

    Causes

    Possible substances that can cause hemolytic anemia include:

    • Anti-malaria drugs (quinine compounds)
    • Arsenic
    • Dapsone
    • Intravenous water infusion (not half-normal saline or normal saline)
    • Metals (chromium/chromates, platinum salts, nickel compounds, copper, lead, cis-platinum)
    • Nitrites
    • Nitrofurantoin
    • Penicillin
    • Phenazopyridine (Pyridium)
    • Rho immune globulin (WinRho)
    • Ribavirin
    • Snake bites (some snake venom contains hemolytic toxins)
    • Sulfonamides
    • Sulfones

    This list is not all-inclusive.

    References

    Schwartz RS. Autoimmune and intravascular hemolytic anemias. In: Goldman L, Ausiello D, eds. Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 163.

    Schrier SL, Price EA. Extrinsic nonimmune hemolytic anemias. In: Hoffman R, Benz EJ, Shattil SS, et al., eds. Hematology: Basic Principles and Practice. 5th ed. Philadelphia, Pa: Elsevier Churchill Livingstone; 2008:chap 48.

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                Review Date: 2/19/2012

                Reviewed By: Linda J. Vorvick, MD, Medical Director, MEDEX Northwest Division of Physician Assistant Studies, University of Washington, School of Medicine; and Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

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