St. Luke's Hospital
Main Number: 314-434-1500 Emergency Dept: 314-205-6990 Patient Billing: 888-924-9200
Find a Physician Payment Options Locations & Directions
Follow us on: facebook twitter Mobile Email Page Email Page Print Page Print Page Increase Font Size Decrease Font Size Font Size
America's 50 Best Hospitals
Meet the Doctor
Spirit of Women
Community Health Needs Assessment
Home > Health Information

Multimedia Encyclopedia

    Print-Friendly
    Bookmarks

    Aplastic anemia

    Aplastic anemia is a condition in which the bone marrowdoes notmake enough newblood cells. Bone marrow is the soft, fatty tissue in the center of bones.

    Causes

    Aplastic anemia results from injury to the blood stem cells. These areimmature cells in the bone marrow that give rise to all other blood cells types. The injury causes a decrease in the number of every type of blood cell. These cells are the red cells, white cells, and platelets.

    Aplastic anemia canalso be caused by certain medical conditions such as pregnancy or lupus. Exposure tocertain toxins or medicines, including chemotherapy, can also lead to aplastic anemia.

    Symptoms

    Symptoms resultfrom thebone marrow not being able to make new blood cells. Symptoms may be severe from the start or gradually worsen over time.

    Low red cell count (anemia) can cause:

    • Fatigue
    • Pallor (paleness)
    • Rapid heart rate
    • Shortness of breath with exercise
    • Weakness
    • Lightheadedness upon standing

    Low white cell count (leukopenia) causes an increased risk of infection.

    Low platelet count (thrombocytopenia) can result in bleeding. Symptoms include:

    • Bleeding gums
    • Easy bruising
    • Frequent or severe infections
    • Nose bleeds
    • Rash--small pinpoint red marks on the skin (petechiae)

    Exams and Tests

    The health care provider will perform a physical exam.

    Blood tests will show:

    • Low red blood cell count (anemia)
    • Low white blood cell count
    • Low reticulocyte count (reticulocytes are immature red blood cell)
    • Low platelet count

    A bone marrow biopsy shows fewer-than-normal blood cells and an increased amount of fat.

    Treatment

    Mild cases of aplastic anemia may require no treatment. Symptomsare treated as needed.

    If blood counts become lower, patients receive extra blood and platelets through transfusions. Over time, transfusions may stop working, resulting in very lowblood cell counts. This is a life-threatening condition.

    Bone marrow transplant or stem cell transplantmay berecommended for patients under age 40. This treatment works best when the donor is a fully-matchedbrother or sister. This is called a matched sibling donor.

    Older patients and those who do not have a matched sibling donor are givenmedicinesto suppress the immune system. These medicines may allow the bone marrow to once again make healthy blood cells. But the disease may return (relapse). A bone marrow transplant with an unrelated donor may be tried if these medicines do not help or if the disease comes back after getting better

    Outlook (Prognosis)

    Untreated, severe aplastic anemia leads to rapid death. Bone marrow transplant is very successful in young people. It is alsoused in older patients or whenthe disease comes back after medicines have been tried.

    Possible Complications

    • Severe infections or bleeding
    • Complications of bone marrow transplant
    • Reactions to medicines
    • Hemochromatosis (buildup of too much iron in the body tissuesfrom many red cell transfusions)

    When to Contact a Medical Professional

    Call your health care provider or go to the emergency room if bleeding occurs for no reason, or if bleeding ishard to stop. Call if you notice frequent infections or unusual fatigue.

    References

    Bagby GC. Aplastic anemia and related bone marrow failure states. In: Goldman L, Schafer AI, eds. Goldman’s Cecil Medicine. 24th ed. Philadelphia, PA: Elsevier Saunders; 2011:chap 168.

    Young NS, Maciejewski JP. Aplastic anemia. In: Hoffman R, Benz EJ Jr, Silberstein LE, et al., eds. Hematology: Basic Principles and Practice. 6th ed. Philadelphia, PA: Elsevier Saunders; 2012:chap 28.

    BACK TO TOP

    • Bone marrow aspiration

      illustration

    • Antibodies

      illustration

      • Bone marrow aspiration

        illustration

      • Antibodies

        illustration

      A Closer Look

        Self Care

          Tests for Aplastic anemia

            Review Date: 3/4/2013

            Reviewed By: Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by A.D.A.M. Health Solutions, Ebix, Inc., Editorial Team: David Zieve, MD, MHA, Bethanne Black, Stephanie Slon, and Nissi Wang.

            The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
            adam.com

            A.D.A.M. content is best viewed in IE9 or above, Fire Fox and chrome browser.


            Back  |  Top
            About Us
            Contact Us
            History
            Mission
            Locations & Directions
            Quality Reports
            Annual Reports
            Honors & Awards
            Community Health Needs
            Assessment

            Newsroom
            Services
            Brain & Spine
            Cancer
            Heart
            Maternity
            Orthopedics
            Pulmonary
            Sleep Medicine
            Urgent Care
            Women's Services
            All Services
            Patients & Visitors
            Locations & Directions
            Find a Physician
            Tour St. Luke's
            Patient & Visitor Information
            Contact Us
            Payment Options
            Financial Assistance
            Send a Card
            Mammogram Appointments
            Health Tools
            My Personal Health
            mystlukes
            Spirit of Women
            Health Information & Tools
            Clinical Trials
            Health Risk Assessments
            Employer Programs -
            Passport to Wellness

            Classes & Events
            Classes & Events
            Spirit of Women
            Donate & Volunteer
            Giving Opportunities
            Volunteer
            Physicians & Employees
            For Physicians
            Remote Access
            Medical Residency Information
            Pharmacy Residency Information
            Physician CPOE Training
            Careers
            Careers
            St. Luke's Hospital - 232 South Woods Mill Road - Chesterfield, MO 63017 Main Number: 314-434-1500 Emergency Dept: 314-205-6990 Patient Billing: 888-924-9200
            Copyright © St. Luke's Hospital Website Terms and Conditions  |  Privacy Policy  |  Patient Notice of Privacy Policies PDF Sitemap St. Luke's Mobile