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    Hypersensitivity pneumonitis

    Extrinsic allergic alveolitis; Farmer's lung; Mushroom picker's disease; Humidifier or air-conditioner lung; Bird breeder's or bird fancier's lung

    Hypersensitivity pneumonitis is inflammation of the lungs due to breathing in a foreign substance, usually certain types of dust, fungus, or molds.

    Causes

    Hypersensitivity pneumonitis usually occurs in people who work in places where there are high levels of organic dusts, fungus, or molds.

    • Bird fancier's lung is the most common type of hypersensitivity pneumonitis. It is caused by repeated or intense exposure to proteins found in the feathers or droppings of many species of birds.
    • Farmer's lung is caused by exposure to dust from moldy hay, straw, and grain.

    These exposures can lead to lung inflammation and acute lung disease. Over time, this acute condition may turn into long-lasting (chronic) lung disease.

    Hypersensitivity pneumonitis may also be caused by fungi or bacteria in humidifiers, heating systems, and air conditioners found in homes and offices. Exposure to certain chemicals, such as isocyanates or acid anhydrides, can also lead to hypersensitivity pneumonitis.

    Symptoms

    Symptoms of acute hypersensitivity pneumonitis may occur 4 - 6 hours after you have left the area where the foreign substance is found, making it difficult to find a connection between your activity and the disease.

    Symptoms may include:

    • Chills
    • Cough
    • Fever
    • Malaise (feeling ill)
    • Shortness of breath

    Symptoms of chronic hypersensitivity pneumonitis may include:

    • Breathlessness, especially with activity
    • Cough, often dry
    • Loss of appetite
    • Unintentional weight loss

    Exams and Tests

    Your doctor may hear abnormal lung sounds called crackles (rales) when listening to your chest with a stethoscope.

    Lung changes due to chronic hypersensitivity pneumonitis may be seen on a chest x-ray. Other tests may include:

    • Aspergillus precipitins test
    • Bronchoscopy with washings, biopsy, and bronchoalveolar lavage
    • CBC
    • High-resolution CT scan of the chest
    • Hypersensitivity pneumonitis antibody panels
    • Krebs von den Lungen-6 assay (KL-6)
    • Pulmonary function tests
    • Video-assisted or open-lung biopsy

    Treatment

    First, the foreign substance must be identified. Treatment involves avoiding this substance in the future. Some people may need to change jobs if they cannot avoid the substance at work.

    If you have a chronic form of this disease, your doctor may recommend that you take glucocorticoids (powerful anti-inflammatory medicines). Sometimes treatments used for asthma can help people with hypersensitivity pneumonitis.

    Outlook (Prognosis)

    Most symptoms go away when you avoid or limit your exposure to the material that caused the problem.

    Possible Complications

    The chronic form of this disease may lead to pulmonary fibrosis (a scarring of the lung tissue that often is not reversible).

    When to Contact a Medical Professional

    Call your health care provider if you develop symptoms of hypersensitivity pneumonitis.

    Prevention

    The chronic form can be prevented by avoiding the material that causes the lung inflammation.

    References

    Rose CS, Lara AR. Hypersensitivity pneumonia. In: Mason RJ, Broaddus VC, Martin TR, et al, eds. Murray and Nadel's Textbook of Respiratory Medicine. 5th ed. Philadelphia, Pa: Saunders Elsevier; 2010:chap 66.

    Samet JM. Occupational pulmonary disorders. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 93.

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    • Bronchoscopy

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    • Respiratory system

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      • Bronchoscopy

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      • Respiratory system

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      Self Care

        Tests for Hypersensitivity pneumonitis

          Review Date: 6/10/2011

          Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; and Denis Hadjiliadis, MD, Assistant Professor of Medicine, Division of Pulmonary, Allergy and Critical Care, University of Pennsylvania, Philadelphia, PA. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

          The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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